In 1957, British Overseas Airways Corporation (BOAC) began supplying technical support after acquiring a 6.5 percent shareholding, which it held for about 20 years. New aircraft including Vickers Viscounts, Fokker F27s and more Douglas DC-3s were added to the fleet in the late 1950s and early 1960s.

Turkish Airlines began operating their first jet, a McDonnell Douglas DC-9, in 1967. This was followed by the addition of three Boeing 707 jets in 1971. Other aircraft operated in the early 1970s included the McDonnell Douglas DC-10 and the Fokker F28 which were put into service in 1972 and 1973 respectively.

The versatile Boeing 727-200 was first introduced on December 4, 1974. The airline eventually operated a total of 11 Boeing 727s by the late 1980s. In 1978 new routes to Baghdad, Tehran, and Tripoli began.

The airline was plagued by several issues in the 1980s and 90s. It developed a reputation for poor customer service and delays. It also endured hijackings and suffered seven accidents between 1974 and 1983.

Luckily for the airline, a new government came to power in 1983 which recognized THY's importance as Turkey's gateway to the world, beginning the airline's makeover into a modern operation. (It would go on to maintain one of the youngest fleets in the world). THY built a new, state-of-the-art technical centre at Yeşilköy Airport in 1984. The airline was capable of both light and heavy maintenance on a number of different aircraft types.

By the mid-1980s, THY had a fleet of 30 aircraft, flying to 16 domestic destinations and 36 international. Turkish Airlines began operating Airbus A310s in 1985, allowing the addition of flights to Singapore in 1986. A route to New York City via Brussels was added in 1988. It was at this time, in 1985 that the airline began to roll out a First Class service to all destinations, starting with London and Jeddah. Three improved A310-300s were added to the fleet in 1988. Routes to Helsinki, Tunis, Algeria, Oslo, Basel, and New York were opened that year also.

In 1990, Turkish Airlines underwent a significant corporate identity overhaul to reflect its transition into a modern, global competitor. On September 14, 1990, the airline officially introduced a refined version of its iconic "wild goose" logo, pivoting away from the heavier aesthetic of the previous decades. This rebranding wasn't just cosmetic; it coincided with a fleet modernization program and an upgraded service standard.

In 1991 it introduced the Boeing B737 aircraft into the fleet, to operate domestic routes, the fleet was refurbished both inside and out, including the new aircraft livery. Simultaneously, the uniforms worn by the flight crew and ground personnel were updated.

A total of 8 new aircraft; 6 B737-400s and 2 B737-500s joined the fleet also. In 1993, the fleet was rejuvenated, reducing the average aircraft age to 6.2 years old. RJ-100 aircraft were also added to the fleet in 1993. As for the long haul aircraft, new Airbus A340-300, the first one named "İstanbul" arrived on the 26 July 1996. This milestone allowed the carrier to bypass technical stops and launch its first non-stop service to New York (JFK) in 1993, followed closely by expanded non-stop routes to Tokyo (Narita) and Hong Kong.

The addition of Airbus 340s introduced a 3-tier service with First Class, Business Class, and Economy Class.

However with an eye on further expansion the company suffered in the global aviation crisis following the Persian Gulf War and would not break even again until 1994. However, business was again booming in the mid-1990s, with the greatest growth coming from North American destinations. The domestic market was deregulated in 1996, allowing new scheduled competition from charter airlines. At the same time, larger international carriers were providing stiff competition on routes to Western Europe. THY entered into marketing agreements with other international airlines to enhance their competitiveness. In 1995 three B737-400s, two RJ-100s, seven B737-400s, and three RJ-100s were added to the fleet.

The company teamed with Japan Airlines to offer service to Osaka and Tokyo in 1997 and 1998. Other jointly operated flights soon followed with Austrian Airlines, Swissair, and Croatia Airlines. In 1998 six new generation B-737-800 aircraft were added to the fleet, soon after the airline realised the potential of the airframe and ordered over 100 examples to be delivered over the next decade.

A new terminal opened in January 2000 at Istanbul's Istanbul Atatürk Airport. Turkish Airlines continued to extend their international reach, forging marketing agreements with Asiana Airlines, American Airlines, Malaysia Airlines, LOT Polish Airlines, Czech Airlines and Cathay Pacific in 2000. Turkey underwent an economic crisis throughout most of 2001, leading to a reduction in traffic on domestic routes in particular. THY managed to survive after the September 11 attacks in the United States without a government bailout or mass layoffs. In 2003, the war in Iraq prompted Turkish Airlines to close some routes in the Persian Gulf, while flights to Asia were suspended during the SARS epidemic.

However, the airline soon recorded increasing traffic on existing routes and adding services to Delhi after an 11-year lapse. Another fleet expansion program kicked off in 2004, helping THY maintain one of the youngest fleets in Europe. In July that year, the airline announced a massive order of 36 jets from Airbus, plus an order for 15 Boeing 737s. THY was not just ordering new planes. It was planning to spend on a new technical and training facility at Istanbul's underutilized Sabiha Gökçen International Airport.

The airline faced the entry of new competitors into the liberalizing Turkish aviation market. However, tourism was booming. Although the company was publicly traded at this time, the government owned 98% of its shares. The privatization program was revived in 2004 with a public offering of 20% of shares on the Istanbul Stock Exchange.

In 2005 another large order followed, the largest in the history of Turkish Airlines, for Fifty-nine new aircraft consisting of 36 Airbus A330-200, A321-200, and A320-200 aircraft, and 23 B-737-800s from Boeing. Also the airline begun a dramatic expansion plan, that year alone it opened 23 new international routes. The first 3 of the 59 aircraft ordered from Airbus and Boeing arrived, the new generation Boeing 737-800, an Airbus A320, and Turkey’s first Airbus A330. In July 2006, Turkish first Airbus A321 (TC-JRA) also arrived, which it later painted in the Star Alliance livery.

On 1 April 2008, Turkish Airlines joined the Star Alliance after an 18-month integration process. In 2009 new routes went into service, flying to Uşak, Çanakkale, Ufa, Mashhad, Dakar, Sao Paolo, Benghazi, Gothenburg, Toronto, Lviv, and Jakarta.

In April 2010, TURKISH replaced TURKAIR as the new call sign for Turkish Airlines. New domestic and global routes were opened from the turn of the new decade, Dar es Salaam and Entebbe, Sochi, Accra, Washington, D.C amongst many more. Turkish Airline set it's target to fly to over 200 destinations worldwide and become one of the leading airlines in the world. At the same time, Istanbul Ataturk Airport began to expand into a major continental transit hub, but it was reaching capacity so a plan was underway to relocate to a new airport later in the decade.

New aircraft like the Airbus A330-300 arrived in October 2010 to cope with the expansion as well as it started leasing Boeing 777-300 from Jet Airways till it's pre-owned aircraft arrived later in October 2010. More routes opened to Guangzhou, Shiraz, Valencia, Erbil, Toulouse, Malaga, Genoa, Basra, Thessaloniki, Naples, Najaf, Kabul, Sulaymaniyah, Islamabad, and Turin in 2011. It continued to take delivery as well as many more Airbus A321, which become the backbone of the European fleet, operating up to 69 examples.

The fleet saw a major upgrade with the arrival of the first Boeing 777-300ER on October 13, 2010. The aircraft, registered as TC-JJE and named "Dolmabahçe," was delivered at Boeing’s Everett facility in Washington and arrived in Istanbul the following day, October 14, 2010. It went on to become one of the symbols of the long haul network for Turkish Airlines for over 2 decades.

In December 2011, Turkish received its first Boeing 737-900, a slighter bigger version of the Boeing classic aircraft for use on its more dense domestic routes. The same time, with its expansion plans in December 2011, the Turkish government together with THY unveiled the news to modernize the Aden Adde International Airport in Mogadishu, Somalia. In March 2012, Turkish Airlines became the first international carrier to resume flights to Somalia since the start of that country's civil war in the early 1990s. In 2012 it launched new routes to some of the countries which no other airline would dare to fly to, flying to Irak, Somalia or Afghanistan for example. By the end of 2013, Turkish Airlines had increased their number of flight points to 241 destinations worldwide (199 international and 42 domestic).

In 2013, the airline won the distinction to became the airlines that flies to the most countries and destinations in the world. The airline embarked on a global campaign and marketing strategy which made planes wear liveries of football and basketball teams and the airline was the official sponsor for many sporting events, giving it international brand recognition. The lounge at Istanbul Ataturk was upgraded for it's frequent travellers and this also won "best Lounge Awards". It also introduced a service called "Tourİstanbul" for passengers in transit and with time to visit the city.

The transition of Turkish Airlines to its massive new hub was a multi-year endeavour. While the Turkish government initiated the project, the formal bidding process concluded on May 3, 2013, with the ground-breaking officially took place on June 7, 2014, and construction began in May 2015.

However, with increased competition from the middle east, in August 2016, Turkish Airlines announced a profit collapse, the airline announced significant reductions in operations for the upcoming 2016/2017 schedule period with frequency cuts to 45 European and 13 intercontinental routes. Despite it, it added Bogota, Panama, Dubrovnik, Atlanta, Kosice, Hanoi, Cluj, Victoria, Zanzibar, Havana, and Caracas to its worldwide map.